pentobarbital will lower the extent or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Suggested atogepant dosage with concomitant use of robust or reasonable CYP3A4 inducers is 30 mg or sixty mg qDay.pentobarbital will lower the level or result of ibuprofen by affecting hepatic enzyme CY